||The First Affiliated Hospital
||Mechanism and treatment of viral hepatitis
|Personal Home Page:
Experience and Professional Memberships
1.Chinese Medical Society for Liver Diseases
2.Chinese Medical Society for Tropical Diseases and Parasitic Diseases
3.Zhejiang Medical Society for Infectious Diseases and Parasitic DiseasesParasitic Diseases(Chairman)
4.Zhejiang Medical Society for Virology (Vice-Chairman)
5.Zhejiang Medical Society for Liver Diseases
6.Zhejiang Society for Microbiology (President)
7.Zhejiang Society for bioengineering (Vice-President)
Areas of Specialization: Viral hepatitis
11978-1983，M.D., Zhejiang Medical University (Now Medical School, Zhejiang University), Clinical Medicine
1986-1989，M.S, Zhejiang Medical University,Infecious Diseases
1989-1992，Ph.D, Zhejiang Medical University,Infecious Diseases
1992.9-1993.10, Postdoc, Department of Microbiology, Medical University of Lübeck, Lübeck,Germany ,Infecious Diseases/ Virology
Positions and Employment
Professor (1998-present) Institute of Infectious Diseases, Zhejiang University
Associate Professor (1994-1998) Institute to Infectious Diseases, Zhejiang University
Vice-Dean (10/2001-present), Medical School, Zhejiang University
Vice-Director (01/1991-01/1998 Institute of Infectious Diseases, Zhejiang Medical University
Director (01/1998-2008), Institute of Infectious Diseases, Zhejiang University
Vice-Director (2008-present), State key lab for Diagnosis and Treatment of Infectious Diseases, Institute of Infectious Diseases, Zhejiang University
Selected Peer-Reviewed Publications
TAN Xu-fei, CHEN-Feng, WU Shan-shan, Shi Yu, LIU Dong-cheng, CHEN Zhi. Proteomic Analysis in the Liver Injuried Mice Inducible by Concanavalin A, JZUS-B ，2010，11（3）:221-226
Li J, Chen F, Zheng M, Zhu HH, Zhao DJ, Liu WX, Liu W, Chen Z. Inhibition of STAT1 methylation is involved in the resistance of Hepatitis B Virus to Interferon alpha. Antiviral Research, Anti Res，2010,85(3): 463-469
Qing-yi CAO, Feng CHEN, Jie LI, Shan-shan WU, Jing WANG, Zhi CHEN.A microarray analysis of early activated pathways in concanavalin A-induced hepatitis. JZUS-B, 2010，11（5）：366-377
FENG CHEN, HAI-HONG ZHU, LIN-FU ZHOU,et al. Inhibition of c-FLIP expression by miR-512-3p contributes to Taxol-induced apoptosis in hepatocellular carcinoma cells ，Oncology Report，2010，23（5）：1457-1462。1.524(973，11-5)
Xiao-E Lou, Ning Xu, Hang-Ping Yao, Zhi Chen. Bicyclol attenuates pro-inflammatory cytokine and chemokine productions in CpG-DNA-stimulated L02 hepatocytes by inhibiting p65-NF-KappaB and p38-MAPK activation. Pharmazie, 2010:206-212. （11－5，973，国家基金）
Wei Wu, Jie Li, Feng Chen, Haihong Zhu, Guoping Peng and Zhi Chen. Circulating Th17 cells frequency is associated with the disease progression in HBV infected patients. Journal of Gastroenterology and Hepatology, 2010, 25:750-757
Chen X, Fu S, Chen F, Chen H, Chen Z. Identification of tumor-associated antigens in human hepatocellular carcinoma by autoantibodies. Oncol Rep. 2008 Oct;20(4):979-85.
Hou XL, Cao QY, Jia HY, Chen Z. Pyrosequencing analysis of the gyrB gene to differentiate bacteria responsible for diarrheal diseases. Eur J Clin Microbiol Infect Dis. 2008 Jul;27(7):587-96. Epub 2008 Mar 7.
Peng GP, Sun W, Wu W, Sun Z, Tan XF, Li SP, Chen Z. PD-L1 expression in circulating dendritic cells of patients with chronic hepatitis B. Journal of Zhejiang University (Medical Sciences) 2008 Jul;37(4):364-72. Chinese.
Hou XL, Jiang HL, Cao QY, Zhao LY, Chang BJ, Chen Z. Using oligonucleotide suspension arrays for laboratory identification of bacteria responsible for bacteremia. J Zhejiang Univ Sci B. 2008 Apr;9(4):291-8.
Zhou C, Kang XD, Chen Z. A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen. J Zhejiang Univ Sci B. 2008 Apr;9(4):279-85.
Xu N, Yao HP, Sun Z, Chen Z. Toll-like receptor 7 and 9 expression in peripheral blood mononuclear cells from patients with chronic hepatitis B and related hepatocellular carcinoma. Acta Pharmacol Sin. 2008 Feb;29(2):239-44.
Peng G, Li S, Wu W, Tan X, Chen Y, Chen Z. PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients. Mol Immunol. 2008 Feb;45(4):963-70. Epub 2007 Sep 14.
Peng G, Li S, Wu W, Sun Z, Chen Y, Chen Z. Circulating CD4+ CD25+ regulatory T cells correlate with chronic hepatitis B infection. Infection.Immunology. 2008 Jan;123(1):57-65. Epub 2007 Aug 31.
Zhu HH, Jiang HL, Chen Z.A high-throughput diagnostic method for detecting pathogenic microbes. Journal of Zhejiang University (Medical Science). 2007 Nov;36(6):524-30. Chinese.
Huang YS, Chen Z, Yang ZY, Wang TY, Zhou L, Wu JB, Zhou LF. Preparation and characterization of a potent, long-lasting recombinant human serum albumin-interferon-alpha2b fusion protein expressed in Pichia pastoris. Eur J Pharm Biopharm. 2007, 67(2):301-8. Epub 2007 Feb 25.
Huang YS, Jin R, Liu XN, Wang CM, Rong YW, Chen Z. Study of target pegylated recombinant mutant human granulocyte colony stimulating factor. Chinese Journal of Biotechnology 2007 Sep;23(5):919-23. Chinese.
Tang C, Chen Z, Peng G, Yang Z, Zhou L. Analysis of differential gene expression between chronic hepatitis B patients and asymptomatic hepatitis B carriers.J Gastroenterol Hepatol. 2007 Jan;22(1):68-73.
Hou XL, Cao QY, Pan JC, Chen Z. Classification and identification of vibrio cholerae and vibrio parahaemolyticus isolates based on gyrB gene phylogenetic analysis. Acta Microbiologica Sinica. 2006 Dec;46(6):884-9. Chinese.
Huang Y, Chen Z, Jia H, Wu W, Zhong S, Zhou C. Induction of Tc1 response and enhanced cytotoxic T lymphocyte activity in mice by dendritic cells transduced with adenovirus expressing HbsAg. Clin Immunol. 2006 Jun;119(3):280-90. Epub 2006 Mar 10.
Jiang HL, Zhu HH, Zhou LF, Chen F, Chen Z. Genotyping of human papillomavirus in cervical lesions by L1 consensus PCR and the Luminex xMAP system. J Med Microbiol. 2006 Jun;55(Pt 6):715-20.
Tang CL, Chen Z, Yang ZG, Zhou LF, Chen F, Peng GP. Screening differentially expressed genes of asymptomatic HBV carriers by suppression subtracted hybridization. Chinese Journal of Hepatology. 2006 Apr;14(4):302-3.
Chen Z, Pan XC. hepatitis C and autoimmune diseases. Chinse Journal of Hepatology. 2006 Mar;14(3):236-7.
Pan XC, Chen Z, Chen F, Chen XH, Zhou C, Yang ZG. Mutations of the tumor suppressor Kruppel-like factor 6 (KLF6) gene in hepatocellular carcinoma and its effect of growth suppression on human hepatocellular carcinoma cell line HepG2. Chinese Journal of Hepatology. 2006 Feb;14(2):109-13. Chinese.
Chen F, Chen XM, Chen Z, Jiang HL, Pan XP, Hu ZR, Liu RH, Chen XM. Construction and application of a yeast expression system for thymosin alpha1. Biocell. 2005 Dec;29(3):253-9.
Zumbika E, Ruan B, Xu CH, Ni Q, Hou W, Chen Z, Liu KZ. HBV genotype characterization and distribution in patients with HBV-related liver diseases in Zhejiang Province, P.R. China: possible association of co-infection with disease prevalence and severity. Hepatobiliary Pancreat Dis Int. 2005 Nov;4(4):535-43.
Yan XB, Chen Z, Luo DH, Xu XY, Wu W, Zhou LF. Proapoptotic and pronecrosis effect of different truncated hepatitis C virus core proteins. J Zhejiang Univ Sci B. 2005 Apr;6(4):295-300.
Chen XH, Chen Z, Yao HP, Chen F, Zhu HH, Zhou HJ. Construction and characterization of a cDNA library from human liver tissue with chronic hepatitis B. J Zhejiang Univ Sci B. 2005 Apr;6(4):288-94.
Yang ZG, Chen Z, Ni Q, Pan XC, Jin HY, Li XY. Inhibition of HBs-GFP fusion gene expression by RNA interference. Journal of Zhejiang University (Medical Sciences). 2005 Mar;34(2):110-5.
Chen XH, Chen Z, Chen F, Zhu HH, Zhou HJ, Yao HP.Construction and characterization of a cDNA library from human liver tissue of cirrhosis. Journal of Zhejiang University (Medical Sciences). 2005 Mar;34(2):98-103. Chinese.
Chen Z. Advances in treatment of chronic hepatitis B virus infection. Journal of Zhejiang University (Medical Sciences). 2005 Mar;34(2):95-7. Chinese.
Yang ZG, Chen Z, Ni Q, Xu N, Shao JB, Yao HP. Inhibition of hepatitis B virus surface antigen expression by small hairpin RNA in vitro. World J Gastroenterol. 2005 Jan 28;11(4):498-502.
Yan XB, Chen Z, Delphine B, Nicole P, Christian B. Construction and expression of plasmids containing different truncated core proteins of hepatitis C virus derived from tumor and non-tumor tissues. Chinese Journal of Hepatology. 2004 Nov;12(11):643-7.
Yang ZG, Chen Z, Xu N, Ni Q, Pan XC, Jin HY, Li MW. Establish a screening system for selection of mRNA target sites for HBsAg to construct siRNA with shRNA. Chinese Journal of Hepatology. 2004, 12(9):515-8.
Ni Q, Chen Z, Yao HP, Yang ZG, Liu KZ, Wu LL. Inhibition of human La protein by RNA interference downregulates hepatitis B virus mRNA in 2.2.15 cells. World J Gastroenterol. 2004 Jul 15;10(14):2050-4.
Ni Q, Liu KZ, Yang ZG, Yao HP, Ai DH, Li MW, Chen Z. Development of a system for quick screening of efficient Hbx-siRNA. Journal of Zhejiang University (Medical Sciences). 2004;33(4):300-5, 310.
Huang Y, Chen Z, Zhou C, Yao H, Li M, Xu C. The modulation of thymosin alpha 1 in the maturation, differentiation and function of murine bone marrow-derived dendritic cells in the absence or presence of tumor necrosis factor-alpha. Int Immunopharmacol. 2004 Apr;4(4):539-46.
Zhang P, Chen Z, Chen F, Li MW, Fan J, Zhou HM, Liu JH, Huang Z. Expression of IFN-gamma and its receptor alpha in the peripheral blood of patients with chronic hepatitis C. Chin Med J (Engl). 2004 Jan;117(1):79-82.
Pan XP, Wo JE, Chen Z, Chen F, Liang WF, Liu KZ. Detection and analysis of the new kind of G743C and G743A point mutation of HBV P gene in hepatitis B virus infected patients resistant to lamivudine. Zhonghua Gan Zang Bing Za Zhi. 2003 Oct;11(10):616-8. Chinese.
Shao JB, Chen Z. Expression of MAGE, GAGE, and BAGE genes in human hepatocellular carcinoma. Chinese Journal of Hepatology. 2003 Mar;11(3):142-4.
Chen GY, Chen Z, Li MW, Liu HM, Hu ZR. Modulation and implications in pathogenesis of interferon gamma receptor 1 in patients with chronic hepatitis B. Chinese Journal of Hepatology. 2003 Jan;11(1):14-6.
Shentu J, Zhang B, Fan L, He Q, Yang B, Chen Z. Anti-proliferative activity of fenretinide in human hepatoma cells in vitro and in vivo. Anti-Cancer Drugs 2007, 18:47–53
Sun Z, Zhou L, Zeng H, Chen Z, Zhu H. Multiplex locked nucleic acid probes for analysis of hepatitis B virus mutants using real-time PCR. Genomics. 2006; 89(1):151－9
Chen Z, Zheng M. Patents and development of HBV and HCV clinical treatment: from 2001 to April 2005, Expert Opin. Ther. Patents, 2005;15(8):1027-1039
Shao JB, Chen Z, Ni WQ, Fan J. A quantitative method to detect HBV cccDNA by chimeric primer and real-time polymerase chain reaction. J Virol Methods. 2003 ;112(1-2):45-52
Luo B, Chen Z, Zheng Y, Pan X, Li X. Apolipoprotein E genotype in patients with Alzheimer’s disease. Chinese Medical Journal 2003;116(8):1220-1222
Zhu H, Chen J, Chen Z, et al. The effect of thymosin alpha 1 on expression prof iles of signal transductors involving anti-infection in human lymphocytes. Chin J Infect Dis. 2003;21(3):221 -224
Zhou L, Zhu H, Lin J, Hu M, Chen F, Chen Z. Surveillance of viral contamination of invasive medical instruments in dentistry. J Zhejiang Univ Sci B. 2006;7(9):745-748
CHEN J, Zhu H, CHEN Z, et al. Construction of eukaryotic expression plasmid of murine TLR3 and identification of its biological activity. Chin J Microbiol Immunol. 2004;24(6):447－450
Chen JZ, Zhu HH, Liu KZ, Chen Z. Enhancing cellular immune response to HBV M DNA vaccine in mice by co-delivery of interleukin-18 recombinant. J Zhejiang Univ Sci. 2004; 5 (4):467-471
Pan XC, Chen Z, Ni Q, Yang ZG, Xu N, Jin HY. Application of PCR-based tRNAval Pol III-shRNA expression cassettes in screening of efficient cassettes in screening of efficient siRNA for inhibiting hepatitis B virus. Journal of Zhejiang University (Medical Sciences). 2006, 35 (2):154-160.
Peng GP, Sun W, Sun Z, Zhu JJ, Li SP, Chen Z. PD-1 expression in peripheral T cells of patients with HBV infection and its significance. Journal of Zhejiang University (Medical Sciences). 2007, 36(6): 553-560.
Zhang P, Chen Z, Chen F, Li MW. The expression of chemokine receptor (CCR6) on the periphery lymphocytes in chronic patients infected with hepatitis C virus. Chinese Journal of Infection Control. 2003, 2(4): 246-248
Chen Z. Advances in Hepatitis B virus cccDNA research.(Review) Chinese Journal of Infectious Diseases.2003,21(1).-8-10
Chen GY, Chen Z, Li MW, Liu HM, Hu ZR. Modulation and implications in pathogenesis of interferon gamma receptor 1 in patients with chronic hepatitis B. Chinese Journal of Hepatology, 2003 11(1): 14-16
Pan XP, Wo JE, Chen Z, Chen F, Liang WF, Liu KZ. Detection and analysis of the new kind of G743C and G743A point mutation of HBV P gene in hepatitis B virus infected patients resistant to lamivudine. Chinese Journal of Hepatology. 2003, 11(10): 616-618
Chen Z, Wu NP. Immune reconstitution in the era of highly active antiretroviral therapy. Journal of Zhejiang University (Medical Sciences), 2003, 32 (2): 87-89 (Review)
Luo BY, Chen Z, Li X, Jin HQ, Pan XP, Chen F. Study of apolipoprotein E gene single neucleotide polymorphism in patients with cerebral infarction. Chinese Journal of Preventive Medicine..2003,37(2):143-143
Luo BY, Chen Z, Chen F, Li X, Pan XP. Study of apolipoprotein E gene single nucleoside polymorphism. Chinese Journal of Neurology. 2003, 36(4): 280-282
Zhou HM, Chen Z, Chen GY, Li MW. Effects of TRAIL gene therapy on human hepatocellular carcinoma . Chinese Journal of Oncology.2003,25(2): 152-153
Outstanding Teacher honored by Ministry of Education of P.R.China, 2003
1st Prize of the tenth “Wu Yang Award”, 2008
Study on the New Diagnosis Technology of Infectious Diseases, 1st Science and Technology Progress Awards honored by Zhejiang Province Government. 2007
Building of Lymphocyte model of HCV infection and Used in antiviral study of antisense oligonucleotides. 2nd Science and Technology Progress Awards honored by Zhejiang Province Government. 1998
Relationship between Schistosomiasis japonica and Viral Hepatitis. 3rd Science and Technology Progress Award honored by Zhejiang Province Government. 1997
Ultrasonography in Diagnosis of Schistosomiasis Japonica . Advanced reward in Science and Technology Progress by Zhejiang Province government. 1997
Research on Mother-fetal Transmission of HCV. 2nd Science and Technology Progress Award honored by Zhejiang Province Government.1997
HIV Genotyping and Antigenic Analysis in HIV-infected patients with Drug Addiction. 2nd Science and Technology Progress Award honored by Zhejiang Province Government. 1999
DNA Vaccination Research on Hepatitis C Virus. 2nd Science and Technology Progress Award honored by Zhejiang Province Government.2000
Pathogenesis of Hepatic Fibrosis caused by Schistosomiasis japonica. 2nd Science and Technology Progress Award honored by Zhejiang Province Government. 2000
Prevention of Co-infection of HIV and Hepatitis Virus. 3rd Science and Technology Progress Award honored by Zhejiang Province Government.2003
Pathogenesis and Prevention of SARS in Zhejiang Province. 2nd Science and Technology Progress Award honored by Zhejiang Province Government. 2004
Serum Indices and Peripheral Mononucleocytes indices for Hepatic Fibrosis. 3rd Science and Technology Progress Award honored by Zhejiang Province Government. 2004
Books(Editor in Chief )
Human Viral Infectious Diseases. Published by People's Medical Publishing House (ISBN7-117-04935-9). 2002
National Basic Research Program of China 973 Program 2007CB512905 (Chen, PI) 07/2007-12/2011,Research of monitoring, precautions, and treatment of Hepatitis B aggravation.
National Nature Science Foundation 30771918 (Chen, PI), 01/2008-12/2010, Inhibition of Hepatitis B Virus Replication in Mouse Using Targeted Cell-Penetrating Technology
The State S&T Projects （ 11th Five Year）2008ZX10002-007 (Chen, PI), 01/2008-12/2010,Factors affect the prognosis of serve hepatitis B and its mechanism
The State S&T Projects （ 11th Five Year）2008ZX10002-01 (Chen, PI), 01/2008-12/2010,The investigation of the clinical prognosis of hepatitis C and the treatment of difficult-to-treat HCV